ASPLOS is the premier forum for multidisciplinary systems research spanning computer architecture and hardware, programming languages and compilers, operating systems and networking, as well as applications and user interfaces. The research may target diverse goals such as performance, energy and thermal efficiency, resiliency, security, and sustainability. The importance of such cross-cutting research continues to grow as we grapple with the end of Dennard scaling, the explosion of big data, scales ranging from ultra-low power wearable devices to exascale parallel and cloud computers, the need for sustainability, and increasingly human-centered applications. ASPLOS embraces systems research that directly targets these new problems in new ways.