The 2nd International Workshop on Machine Learning and Deep Learning (WMLDL 2025) is organized by the Laboratory of Informatics and its Applications of M'sila (LIAM), Faculty of Mathematics and Computer Science, and the Artificial Intelligence House of the University Mohamed Boudiaf of M'sila on November 25, 2025, in M’sila, Algeria. After its first edition organized in 2023, WMLDL continues to be a scientific event that provides an excellent international forum for sharing knowledge and results in theory, methodology and applications of Machine Learning and Deep Learning. The Workshop seeks significant contributions to all major fields of both Machine Learning and Deep Learning encompassing both theoretical and practical aspects. The workshop aims to provide a platform for senior researchers, research scholars, and practitioners from both academia and industry to meet and share their research results and experiences on all topics within the ML and DL fields.